name:   Actinobacteriophage_692
version:    2
date:   2016-04-15
owner:
    name:   Graham Hatfull
    email:  gfh@pitt.edu
    url:    https://www.biology.pitt.edu/person/graham-hatfull
description: >
    This database contains the 692 manually annotated Actinobacteriophages analyzed
    in Klyczek et al. 2017.
publications:
    1:
        doi:    10.1371/journal.pone.0180517
        pmid:   28715480
        title:  >
            Tales of diversity: Genomic and morphological characteristics of forty-six
            Arthrobacter phages
        authors:    >
            Karen K Klyczek, J Alfred Bonilla, Deborah Jacobs-Sera, Tamarah L Adair,
            Patricia Afram, Katherine G Allen, Megan L Archambault, Rahat M Aziz,
            Filippa G Bagnasco, Sarah L Ball, Natalie A Barrett, Robert C Benjamin,
            Christophaer J Blasi, Katherine Borst, Mary A Braun, Haley Broomell,
            Conner B Brown, Zachary S Brynell, Ashley B Blue, Sydney O Burke, William
            Casazza, Julia A Cautela, Kevin Chen, Nitish S Chimalakonda, Dylan Chudoff,
            Jade A Connor, Trevor S Cross, Kyra N Curtis, Jessica A Dahlke, Bethany M
            Deaton, Sara J Degroote, Danielle M DeNigris, Katherine C DeRuff, Milan
            Dolan, David Dunbar, Marisa S Egan, Daniel R Evans, Abby K Fahnestock, Amal
            Farooq, Garrett Finn, Christopher R Fratus, Bobby L Gaffney, Rebecca A
            Garlena, Kelley E Garrigan, Bryan C Gibbon, Michael A Goedde, Carlos A
            Guerrero Bustamante, Melinda Harrison, Megan C Hartwell, Emily L Heckman,
            Jennifer Huang, Lee E Hughes, Kathryn M Hyduchak, Aswathi E Jacob, Machika
            Kaku, Allen W Karstens, Margaret A Kenna, Susheel Khetarpal, Rodney A King,
            Amanda L Kobokovich, Hannah Kolev, Sai A Konde, Elizabeth Kriese, Morgan E
            Lamey, Carter N Lantz, Jonathan S Lapin, Temiloluwa A Lawson, In Young Lee,
            Scott M Lee, Julia Y Lee-Soety, Emily M Lehmann, Shawn C London, A Javier
            Lopez, Kelly C Lynch, Catherine M Mageeney, Tetyana Martynyuk, Kevin J
            Mathew, Travis N Mavrich, Christopher M McDaniel, Hannah McDonald, C Joel
            McManus, Jessica E Medrano, Francis E Mele, Jennifer E Menninger, Sierra
            N Miller, Josephine E Minick, Courtney T Nabua, Caroline K Napoli, Martha
            Nkangabwa, Elizabeth A Oates, Cassandra T Ott, Sarah K Pellerino, William
            J Pinamont, Ross T Pirnie, Marie C Pizzorno, Emilee J Plautz, Welkin H Pope,
            Katelyn M Pruett, Gabbi Rickstrew, Patrick A Rimple, Claire A Rinehart,
            Kayla M Robinson, Victoria A Rose, Daniel A Russell, Amelia M Schick,
            Julia Schlossman, Victoria M Schneider, Chloe A Sells, Jeremy W Sieker,
            Morgan P Silva, Marissa M Silvi, Stephanie E Simon, Amanda K Staples,
            Isabelle L Steed, Emily L Stowe, Noah A Stueven, Proter T Swartz, Emma A
            Sweet, Abigail T Sweetman, Corrina Tender, Katrina Terry, Chrystal Thomas,
            Daniel S Thomas, Allison R Thompson, Lorianna Vanderveen, Rohan Varma,
            Hanna L Vaught, Quynh D Vo, Zachary T Vonberg, Vassie C Ware, Yasmene M
            Warrad, Kaitlyn E Wathen, Jonathan L Weinstein, Jacqueline F Wyper, Jakob
            R Yankauskas, Christine Zhang, Graham F Hatfull.
        abstract:   >
            The vast bacteriophage population harbors an immense reservoir of genetic information.
            Almost 2000 phage genomes have been sequenced from phages infecting hosts in the
            phylum Actinobacteria, and analysis of these genomes reveals substantial diversity,
            pervasive mosaicism, and novel mechanisms for phage replication and lysogeny. Here,
            we describe the isolation and genomic characterization of 46 phages from environmental
            samples at various geographic locations in the U.S. infecting a single Arthrobacter sp.
            strain. These phages include representatives of all three virion morphologies, and
            Jasmine is the first sequenced podovirus of an actinobacterial host. The phages also
            span considerable sequence diversity, and can be grouped into 10 clusters according to
            their nucleotide diversity, and two singletons each with no close relatives. However,
            the clusters/singletons appear to be genomically well separated from each other, and
            relatively few genes are shared between clusters. Genome size varies from among the
            smallest of siphoviral phages (15,319 bp) to over 70 kbp, and G+C contents range from
            45–68%, compared to 63.4% for the host genome. Although temperate phages are common
            among other actinobacterial hosts, these Arthrobacter phages are primarily lytic, and
            only the singleton Galaxy is likely temperate.
resources: ~